PREDICTIVE VALUE OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELET-TO-LYMPHOCYTE RATIO, AND SYSTEMIC IMMUNE-INFLAMMATION INDEX FOR NO-REFLOW PHENOMENON AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION

Abstract

Background

One of the major complications of ST-segment elevation myocardial infarction (STEMI) is no-reflow after first percutaneous coronary intervention (PCI). Using inflammatory indicators, its presence may be anticipated.

Objective

In order to evaluate NLR, PLR, and SII's capacity to foretell successful main PCI without reflow.

Place and Duration of Study

From April 2026 to August 2026 at the Department of Cardiology, University of Lahore Hospital.

Methodology

A prospective observational study of 150 STEMI patients received primary PCI was performed. Sample size was determined according to WHO formula. The blood count measurements taken before the procedure were used to compute NLR, PLR, and SII. Coronary flow was ascertained by TIMI grading.

Results

Of 150 patients, 32 (21.3%) developed no-reflow, while 118 (78.7%) achieved normal flow. The frequency of elevated NLR, PLR, and SII were 71.9%, 65.6%, and 78.1% for no-reflow patients, respectively. The strongest predictive association was for SII.

Conclusion

One possible application for NLR, PLR, and SII is to forecast the absence of reflow after initial PCI.