IN-SILICO STUDY OF MODIFIED SORAFENIB DERIVATIVES AS A POTENTIAL VEGFRS INHIBITORS

Abstract

The goal of the current investigation was to assess the binding affinity, interaction patterns, and inhibitory applications of modified sorafenib derivatives (S1–S6) with VEGFR-1 and VEGFR-2 by molecular docking study. Inhibitor-protein interaction was study by using auto dock vina, discovery studio, and PyMol, we examined the molecular interactions of  six modified compounds against VEGFRs in present work, modified drugs shown an excellent inhibitory potential with targeted VEGFRs (-18.17 to -12.83 kcal/mol). Among the tested derivatives S3 and S2 display a good potential and S2 show least inhibitory activity against targeted VEGFR-1 and VEGFR-2. Further experimental validation will lead to a new therapeutic drug discovery for VEGFRs inhibitors.