ASSESMENT OF THE NON-TOXIC BEHAVIOUR OF CHEMICALLY MODIFIED PLANT SEED MUCILAGE USING RATE AS MODEL RODENT SPECIE

Abstract

Active pharmaceutical ingredients (APIs) are vital to the drug development process. APIs can be authorized for use in pharmaceuticals, opening the door to novel treatments, after undergoing extensive testing to guarantee their safety and effectiveness. OECD 402 and 420 criteria were followed while evaluating the acute oral and dermal toxicity of a composite hydrogel made from acrylamide and Salvia spinosa seed mucilage. Four different groups of rats were used as experimental animals. Animals in categories B, C, and D received one dose of composite hydrogel, while animals in category A served as controls and received no treatment. All of the animals remained alive during the 14-day toxicity research period, and no notable negative effects were seen in the animals. The blood analysis and biochemical test were carried out after 14 days. Together, the results demonstrate that the produced composite hydrogel is a safe substance that shows promise as a non-toxic excipient in drug delivery systems.