IMPACT OF LUBRICANT AND PLATELET-RICH PLASMA EYE DROPS IN THE TREATMENT OF DRY EYE DISEASE
Keywords:
Dry eye disease, platelet-rich plasma, lubricating eye drops, tear film, ocular surface.Abstract
Background: Dry Eye Disease (DED) is a disease that gives symptoms of discomfort and instability of tear film. Although traditional forms of lubricants are temporary, platelet rich plasma (PRP) is a less common supplement that has growth factors that can potentially help regenerate lubricants.
Goal: To test the effectiveness of lubricants and PRP eye drops in DED patients in order to assess Tear Film parameters and the symptoms in these patients.
Methods: A total of 30 eyes of 15 patients were given standard lubricant and then they would be given the PRP drops for a period of 7 days. The Ocular Surface Disease Index (OSDI), Tear Break-up Time (TBUT), Schirmer test I and Tear Prism Height (TPH) were used to determine pre and post-treatment values.
Results: PRP therapy significantly improved outcomes: OSDI decreased from 42.13 ± 6.40 to 11.81 ± 4.13, TBUT increased from 4.93 ± 1.28 s to 12.73 ± 2.01 s, Schirmer I from 5.30 ± 1.08 mm to 16.66 ± 3.66 mm, and TPH from 0.25 ± 0.06 mm to 0.71 ± 0.16 mm (p < 0.001).
Conclusion: PRP eye drops have been shown to be an effective treatment to reduce symptoms and improve tear film parameters in DED, and is a promising treatment for regeneration when tear substitutes do not provide enough benefits.
