PREVALENCE OF HYPOMAGNESEMIA ASSOCIATED WITH METABOLIC SYNDROME AMONG ADULT PATIENTS

Abstract

Hypomagnesemia is linked to insulin resistance and metabolic syndrome (MetS), but data from Pakistan are limited. To compare serum magnesium levels between adults with and without metabolic syndrome at “Chandka Medical College Hospital, Larkana”.This cross sectional study (August 2025 to January 2026) enrolled 189 adults aged from 18 to 65 years. The principal investigator measured anthropometrics “waist circumference, blood pressure”, laboratory parameters “serum magnesium, fasting glucose, triglycerides, HDL cholesterol”, and classified “metabolic syndrome (MetS) using National Cholesterol Education Program and Adult Treatment Panel III criteria. Analysis used independent t‑tests and chi‑square tests”. Mean serum magnesium was “0.78 ± 0.27 mg/dL (normal range: 1.8–2.4 mg/dL)”. The prevalence of objectively measured MetS was 14.3 % (27/189). Serum magnesium levels were 0.790 ± 0.290 mg/dL in non MetS participants (n = 162) and 0.737 ± 0.079 mg/dL in MetS participants (n = 27). The difference was not statistically significant (mean difference 0.053 mg/dL, 95 % CI –0.002 to 0.107, p = 0.057). No significant association was found between gender and MetS (p = 0.677). Physical inactivity was present in 60.3 % of the sample. Severe hypomagnesemia is highly prevalent in this Pakistani adult population but is not significantly associated with objectively measured MetS. The near significant trend (p = 0.057) suggests a possible relationship that should be investigated in larger studies. Routine magnesium assessment and population level interventions should be considered.